What are you looking for?

Search by CAS No./ Product Name


    Pramipexole dihydrochloride is the hydrochloride salt of Pramipexole, a benzothiazole derivative. Pramipexole dihydrochloride monohydrate is a medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). It is a dopamine agonist of the non-ergoline class.

    Pramipexole dihydrochloride monohydrate is described chemically as (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate. Its molecular formula is C10H17N3S.2HCl.H2O, and its molecular weight is 302.26.

    Pramipexole dihydrochloride monohydrate is a white to almost white, crystalline powder that is freely soluble in Water, soluble in Methanol, slightly soluble in Alcohol, practically insoluble in Methylene dichloride. Melting range is 296°C to 301°C, with decomposition.

    Clinical Applications

    Pramipexole dihydrochloride monohydrate is indicated for the symptomatic treatment of Parkinson’s disease. It is also indicated for symptomatic treatment of moderate to severe primary Restless legs syndrome.

    Mode of Administration

    Pramipexole dihydrochloride monohydrate is taken by mouth.

    Pharmacological Effects

    Parkinson's Disease

    Through the stimulation of dopamine receptors, Pramipexole is thought to relieve the symptoms of Parkinson's disease. The motor symptoms of Parkinson's disease occur partly due to a reduction of dopamine in the substantia nigra of the brain. Dopamine is an essential neurotransmitter that has major effects on motor movements in humans.

    Restless Legs Syndrome

    Pramipexole likely restores balance to the dopaminergic system, controlling the symptoms of this condition. Restless legs syndrome is thought to occur, in part, through dysfunction of the dopaminergic system, resulting in unpleasant lower extremity symptoms.

    Get in touch with us

      • 0/500