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    Overview

    Naltrexone Hydrochloride is a medication primarily used to manage alcohol use or opioid use disorder by reducing cravings and feelings of euphoria associated with substance use disorder. Its chemical name is 17-(Cyclopropylmethyl)-4,5-α-epoxy-3,14-dihydroxy-morphinan-6-one hydrochloride. Its molecular formula is C20H24ClNO4 and molecular weight is 377.9.

    Naltrexone Hydrochloride is a white to almost white powder that is freely soluble in Water, slightly soluble in Ethanol (96%), practically insoluble in Methylene chloride. Its melting point is 231-233°C.

    Clinical Applications

    Naltrexone Hydrochloride is indicated in the treatment of alcohol dependence and for the blockade of the effects of exogenously administered opioids.

    Mode of Administration

    Naltrexone Hydrochloride is taken by mouth or by injection into a muscle.

    Pharmacological Effects

    Naltrexone and its metabolite 6-beta-naltrexol reverse the effects of opioids by binding to various opioid receptors in the central nervous system (CNS), including the mu-, kappa- and gamma-opioid receptors; opioid effects of analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence are inhibited.

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