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    Overview

    Adenosylcobalamin, also known as coenzyme B12, cobamamide and dibencozide is one of the biologically active forms of vitamin B12. It is used to treat vitamin B12 deficiency due to dietary deficiency or malabsorption.

    Adenosylcobalamin is described chemically as Coα-[α-(5,6-dimethylbenzimidazolyl)]-Coβ-(5'-deoxy-5'-adenosyl)cobamide. Its molecular formula is C72H100CoN18O17P, its molecular weight is 1579.

    Adenosylcobalamin exists as dark red crystals or a powder that is sparingly soluble in Water and insoluble in Ethanol.

    Clinical Applications

    Peripheral Neuropathy - To relieve the symptoms of nerve damage in the feet and hands.
    Vitamin B12 deficiency- To treat dietary deficiency or malabsorption.
    Megaloblastic Anaemia - To treat anaemia due to deficiency of Vitamin B12.

    Mode of Administration

    Adenosylcobalamin should be taken orally.
    It is usually available as a combination with other supplements.

    Pharmacological Effects

    In humans, Adenosylcobalamin plays an essential role in the production of blood and the maintenance of normal cerebral and nervous function in the human body. It is involved in the synthesis of thymidylate, a substance necessary for DNA synthesis.

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