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    Deslanoside is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). It is found in the leaves of Digitalis lanata, the Woolly Foxglove.

    This compound belongs to the class of organic compounds known as cardenolide glycosides and derivatives. These are compounds containing a carbohydrate glycosidically bound to the cardenolide moiety. Deslanoside is chemically described as (3β,5β,12β)-3-[(O-β-D-gluco pyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexo pyranosyl-(1→4)-2,6-dideoxy-β-D-ribo hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide. Its molecular formula is C47H74O19 and molecular weight is 943.09.

    Deslanoside exists as a white crystalline powder that is slightly soluble in Methanol, very slightly soluble in Ethanol, practically insoluble in Water and in Chloroform. Its specific optical rotation is +7° to +9°.

    Clinical Applications

    For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.

    Mode of Administration

    Deslanoside is available in injectable form.

    Pharmacological Effects

    Deslanoside inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular Sodium and Calcium concentrations. Increased intracellular concentrations of Calcium may promote activation of contractile proteins (e.g., actin, myosin). Deslanoside also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

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