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    Overview

    Dexmedetomidine Hydrochloride is a central alpha-2-adrenergic agonist, an imidazole derivate with analgesic, anxiolytic and sedative activities.

    Dexmedetomidine Hydrochloride is the S-enantiomer of Medetomidine Hydrochloride. Chemical name of Dexmedetomidine Hydrochloride is 1H-Imidazole, 4-[1-(2,3-dimethyl phenyl)ethyl]-, monohydrochloride, (S). Dexmedetomidine Hydrochloride has a molecular weight of 236.74 and the molecular formula is C13H16N2.HCl.

    Dexmedetomidine Hydrochloride is a white or almost white powder that is freely soluble in water. Its melting range is 156-158°C.

    Clinical Applications

    Intensive Care Unit Sedation

    Dexmedetomidine Hydrochloride is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting.

    Procedural Sedation

    Dexmedetomidine Hydrochloride is indicated for sedation of non-intubated patients prior to and/or during surgical and other procedures.

    Mode of Administration

    Dexmedetomidine Hydrochloride is available in injectable form.

    Pharmacological Effects

    Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration of mechanical ventilation and delirium among patients in the intensive care unit (ICU).

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