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    Overview

    Methylcobalamin (Mecobalamin, MeCbl, or MeB12) is a cobalamin, a form of vitamin B12. It differs from Cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. From the perspective of coordination chemistry, Methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds.

    Chemical name of Methylcobalamin is Coα-[α-(5,6-dimethyl-1H-benzimidazol-1-yl)]-Coβ-methylcobamide. Its molecular formula is C63H91CoN13O14P and its molecular weight is 1344.40.

    Methylcobalamin appears as dark red crystals or crystalline powder that is sparingly soluble in Water, slightly soluble in Ethanol (99.5%) and practically insoluble in Acetonitrile. Its melting point is 232 to 235°C.

    Clinical Applications

    Methylcobalamin is used to treat vitamin B12 deficiency. Vitamin B12 is important for the brain and nerves and for the production of red blood cells.

    Methylcobalamin is sometimes used in people with pernicious anaemia, diabetes, and other conditions.

    Mode of Administration

    Methylcobalamin can be administered via intranasal, oral and parenteral routes.

    Pharmacological Effects

    Methylcobalamin is an active form of vitamin B12 that helps in synthesis of methionine and S-adenosylmethionine. It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis. It is a beneficial drug to most of the common disorders like cardiovascular disorders, diabetes, anemia, hyperhomocysteinemia and degenerative disorders. Methylcobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promote neurons to function in proper way and thus improves Alzheimer’s disease, Parkinsonism, Dementia and neuropathic syndromes. It is an approved treatment for peripheral neuropathy.

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