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    Monoammonium glycyrrhizinate is an ammonium salt of glycyrrhizin, which is the major triterpenoid saponin of licorice root (Glycyrrhiza glabra). It has been widely used for the treatment of various inflammatory-based skin diseases. Therefore, its various delivery systems have been reported. It is also an agonist of the human sweet taste receptor, and is known to be a natural sweetener.

    Chemical name of Monoammonium glycyrrhizinate is azanium;(2S,3S,4S,5R,6S)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylate. Its molecular formula is C42H65NO16 and molecular weight is 839.96.

    Monoammonium glycyrrhizinate is a white to yellowish-white powder that is slightly soluble in Water, very slightly soluble in anhydrous Ethanol and practically insoluble in Acetone. Its Melting point is about 209°C.

    Clinical Applications

    Monoammonium glycyrrhizinate is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.

    Mode of Administration

    Topical and oral.

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