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    Overview

    Cabergoline is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson's disease etc.

    The chemical name for Cabergoline is 1-[(6-Allylergolin-8β-yl)-carbonyl]-1-[3-(dimethylamino) propyl]-3-ethylurea. Its molecular formula is C26H37N5O2 and its molecular weight is 451.60. Cabergoline is a white or almost white powder that is freely soluble in Alcohol (96%), slightly soluble in 0.1M Hydrochloric acid, very slightly soluble in Hexane, practically insoluble in Water. Its melting point is 97.5 to 100.5°C.

    Clinical Applications

    For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.

    Mode of Administration

    Cabergoline is given orally as a tablet. It is usually taken with or without food two times a week.

    Pharmacological Effects

    Cabergoline is an ergot medication and works by blocking the release of prolactin from the pituitary gland. The secretion of prolactin by the anterior pituitary is mainly under hypothalamic inhibitory control, likely exerted through release of dopamine by tuberoinfundibular neurons. Cabergoline is a long-acting dopamine receptor agonist with a high affinity for D receptors. Results of in vitro studies demonstrate that Cabergoline exerts a direct inhibitory effect on the secretion of prolactin.

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