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    Overview

    Indacaterol maleate is used for treatment of Chronic Obstructive Pulmonary Disease. It has a role as a beta-adrenergic agonist and a bronchodilator agent. The maleate salt is obtained by reaction of Indacaterol with one equivalent of Maleic acid.

    The chemical name of Indacaterol maleate is (R)-5-[2-(5,6-Diethylindan-2-ylamino)-1- hydroxyethyl]-8-hydroxy-1H-quinolin-2-one maleate corresponding to the molecular formula C24H28N2O3.C4H4O4 and molecular weight of 508.56.

    Indacaterol maleate appears as a white to slightly greyish or slightly yellowish powder that is freely soluble in N-Methyl pyrrolidone and practically insoluble in Ethyl acetate. Its melting point is 195-197°C (dec.)

    Clinical Applications

    Indacaterol maleate is used for the treatment of Chronic Obstructive Pulmonary Disease (COPD). It is delivered as an aerosol formulation through a dry powder inhaler.

    Mode of Administration

    Indacaterol inhalation comes as a powder-filled capsule to inhale by mouth using a special inhaler.

    Pharmacological Effects

    Indacaterol works by stimulating adrenergic beta-2 receptors in the smooth muscle of the airways. This causes relaxation of the muscle, thereby increasing the diameter of the airways, which become constricted in asthma and COPD. It is also long-acting due to its high affinity to the lipid raft domains in the airway membrane so it slowly dissociates from the receptors. Indacaterol also has a high intrinsic efficacy, so it is also very rapid acting.

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