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    Overview

    Neostigmine Methylsulfate is a prescription medicine used to treat the symptoms of Myasthenia gravis, reversal of non-depolarizing neuromuscular blockade and post-operative distention or urinary retention. Neostigmine Methylsulfate belongs to a class of drugs called Acetylcholinesterase Inhibitors, Peripheral.

    Neostigmine Methylsulfate is chemically described as Benzenaminium,3-[[(Dimethylamino) carbonyl]oxy]-N, N, N-trimethyl-, methyl sulfate. Its molecular formula is C13H22N2O6S and molecular weight is 334.39.

    Neostigmine Methylsulfate is a white or almost white crystalline powder that is very soluble in Water and freely soluble in Ethanol (96%). Its melting range is 144-149°C.

    Clinical Applications

    A cholinesterase inhibitor used in the treatment of Myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

    Mode of Administration

    Neostigmine can be given as an intramuscular (IM), intravenous (IV) or subcutaneous (SC) injection.

    Pharmacological Effects

    Neostigmine Methylsulfate is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. The drug inhibits acetylcholinesterase which is responsible for the degradation of acetylcholine. So, with acetylcholinesterase inhibited, more acetylcholine is present. By interfering with the breakdown of acetylcholine, Neostigmine indirectly stimulates both nicotinic and muscarinic receptors which are involved in muscle contraction.

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