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    Overview

    Brivaracetam is a racetam derivative with anticonvulsant (antiepileptic) properties. Chemical name of Brivaracetam is (2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl] butanamide. Its molecular formula is C11H20N2O2 and molecular weight is 212.29.

    Brivaracetam is a white to off-white coloured powder that is very soluble in Dimethyl formamide and freely soluble in Methanol. Its melting point is 72 to 77°C.

    Clinical Applications

    Brivaracetam is an anticonvulsant used for the treatment of partial-onset seizures.

    Mode of Administration

    Brivaracetam is administered by oral or intravenous routes.

    Pharmacological Effects

    Brivaracetam functions by binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain with high affinity. SV2A is known to play a role in epileptogenesis through modulation of synaptic GABA release. It is thought that Brivaracetam exerts its anti-epileptogenic effects through its binding to SV2A. Brivaracetam is also known to inhibit Na+ channels which may also contribute to its anti-epileptogenic action.

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