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    Digoxin is a cardiotonic drug. It is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and congestive heart failure that cannot be controlled by other medication.

    Digoxin is extracted from the leaves of Digitalis lanata.

    Digoxin is described chemically as 3β-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-5β-card-20(22)-enolide. Its molecular formula is C41H64O14, its molecular weight is 780.95.

    Digoxin exists as white to almost white powder that melts with decomposition above 230°C. The drug substance is practically insoluble in Water, slightly soluble in Ethanol (96%) and soluble in a mixture of equal volumes of Methanol and Methylene dichloride.

    Clinical Applications

    Digoxin is used in the treatment of heart failure and in certain supraventricular arrhythmias, particularly atrial fibrillation and atrial flutter.

    Mode of Administration

    Digoxin is most often administered orally. It can also be given as a slow intravenous infusion in an emergency, although this is rarely necessary.

    Pharmacological Effects

    Digoxin increases the force of contraction of the heart and slows the resting heart rate. It also slows conduction through the atrioventricular node and works in this way to terminate or reduce the risk of recurrence of supraventricular tachycardia.

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