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    Mirtazapine is a tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.

    Mirtazapine has a tetracyclic chemical structure and belongs to the piperazino-azepine group of compounds. It is chemically described as (±)-2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine. Its molecular formula is C17H19N3 and molecular weight is 265.36.

    Mirtazapine is a white to creamy white crystalline powder which is slightly soluble in Water, soluble in Methanol and Chloroform. Its melting point is 114 to 116°C.

    Clinical Applications

    Mirtazapine is indicated for the treatment of major depressive disorder and its associated symptoms.

    Mirtazapine has been used off-label for a variety of conditions including panic disorder, generalized anxiety disorder, dysthymia, tension headaches, hot flushes, Post-Traumatic Stress Disorder (PTSD), sleep disorders, substance abuse disorders and sexual disorders, among others.

    Mode of Administration

    Mirtazapine is taken by mouth (tablets).

    Pharmacological Effects

    The mechanism of action of Mirtazapine may be explained by its effects on central adrenergic and serotonergic activity. This drug exhibits a fast onset of action, a high level of response, a manageable side-effect profile and dual noradrenergic and serotonergic effects that are unique from the effects of other antidepressants.

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