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    Nepafenac is an ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Nepafenac is a prodrug of Amfenac, an inhibitor of COX-1 and COX-2 activity.

    Chemical name of Nepafenac is 2-amino-3-benzoyl benzene acetamide. Its molecular formula is C15H14N2O2 and molecular weight is 254.29.

    Nepafenac is a yellow crystalline powder that is soluble in Dimethyl sulfoxide, slightly soluble in Acetone, Methanol and Chloroform, practically insoluble in Water. Its melting point is 178-180°C.

    Clinical Applications

    Nepafenac is indicated for use in the treatment of pain and inflammation following cataract surgery.

    Mode of Administration

    Nepafenac is administered as Topical eye drops.

    Pharmacological Effects

    After topical ocular dosing, Nepafenac penetrates the cornea and is converted by ocular tissue hydrolases to Amfenac, a non-steroidal anti-inflammatory drug. Amfenac is thought to inhibit the action of prostaglandin H synthase (cyclooxygenase), an enzyme required for prostaglandin production.

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